# How to fix ModuleNotFoundError: No module named 'skmisc'?
**URL:** https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817
**Category:** Help
**Created:** [October 12, 2022, 7:54pm UTC](https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817 "2022-10-12T19:54:55Z")
**Posts on this page:** 6
**Page:** 1
### Author:  [@Chris](https://discourse.scverse.org/u/Chris)
#### Post date: [October 12, 2022, 7:54pm UTC](https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817/1 "2022-10-12T19:54:55Z")
Hi all,
After running as instruction message I still got error:
```auto
pip install --user scikit-misc
sc.pp.highly_variable_genes(adata, n_top_genes = 2000, subset = True, flavor = 'seurat_v3')
```
ModuleNotFoundError Traceback (most recent call last) /usr/local/lib/python3.7/dist-packages/scanpy/preprocessing/\_highly\_variable\_genes.py in \_highly\_variable\_genes\_seurat\_v3(adata, layer, n\_top\_genes, batch\_key, check\_values, span, subset, inplace) 52 try: —\> 53 from skmisc.loess import loess 54 except ImportError:
ModuleNotFoundError: No module named ‘skmisc’
During handling of the above exception, another exception occurred:
ImportError Traceback (most recent call last) 2 frames /usr/local/lib/python3.7/dist-packages/scanpy/preprocessing/\_highly\_variable\_genes.py in \_highly\_variable\_genes\_seurat\_v3(adata, layer, n\_top\_genes, batch\_key, check\_values, span, subset, inplace) 54 except ImportError: 55 raise ImportError( —\> 56 ‘Please install skmisc package via `pip install --user scikit-misc’ 57 ) 58 df = pd.DataFrame(index=adata.var\_names)
ImportError: Please install skmisc package via `pip install --user scikit-misc
* * *
NOTE: If your import is failing due to a missing package, you can manually install dependencies using either !pip or !apt.
To view examples of installing some common dependencies, click the
## “Open Examples” button below.
The code is from: [sanbomics\_scripts/single\_cell\_analysis\_complete\_class.ipynb at main · mousepixels/sanbomics\_scripts · GitHub](https://github.com/mousepixels/sanbomics_scripts/blob/main/single_cell_analysis_complete_class.ipynb)
Thank you so much!
---
### Author:  [@willyroqueb](https://discourse.scverse.org/u/willyroqueb)
#### Post date: [December 9, 2022, 10:57pm UTC](https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817/2 "2022-12-09T22:57:12Z")
How did you solve this issue? having the same problem
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### Author:  [@adamgayoso](https://discourse.scverse.org/u/adamgayoso)
#### Post date: [December 10, 2022, 2:57am UTC](https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817/3 "2022-12-10T02:57:37Z")
Perhaps just try `pip install skmisc`? or if you’re in a conda environment `conda install -c conda-forge scikit-misc`
---
### Author:  [@willyroqueb](https://discourse.scverse.org/u/willyroqueb)
#### Post date: [December 10, 2022, 12:51pm UTC](https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817/4 "2022-12-10T12:51:44Z")
> [@adamgayoso](#):
>
> conda install -c conda-forge scikit-misc
No luck with any of those options. I keep getting the same error. It’s driving me crazy because I can run it well on google colab.
## Output exceeds the size limit. Open the full output data in a text editor
ImportError Traceback (most recent call last)
File c:\Users\user\miniconda3\lib\site-packages\scanpy\preprocessing\_highly\_variable\_genes.py:53, in \_highly\_variable\_genes\_seurat\_v3(adata, layer, n\_top\_genes, batch\_key, check\_values, span, subset, inplace)
52 try:
—\> 53 from skmisc.loess import loess
54 except ImportError:
File ~\AppData\Roaming\Python\Python39\site-packages\skmisc\loess\__init_\_.py:51
1 “”"
2 =================================================
3 Locally-weighted regression (:mod:`skmisc.loess`)
(…)
49 pp. 829–836. 1979.
50 “”"
—\> 51 from .\_loess import (loess, loess\_model, loess\_inputs, loess\_control,
52 loess\_outputs, loess\_prediction,
53 loess\_confidence\_intervals, loess\_anova)
56 **all** = [‘loess’, ‘loess\_model’, ‘loess\_control’, ‘loess\_inputs’,
57 ‘loess\_model’, ‘loess\_outputs’, ‘loess\_prediction’,
58 ‘loess\_confidence\_intervals’, ‘loess\_anova’]
ImportError: DLL load failed while importing \_loess: The specified module could not be found.
During handling of the above exception, another exception occurred:
…
57 )
58 df = pd.DataFrame(index=adata.var\_names)
59 X = adata.layers[layer] if layer is not None else adata.X
ImportError: Please install skmisc package via `pip install --user scikit-misc
---
### Author:  [@Chris](https://discourse.scverse.org/u/Chris)
#### Post date: [April 11, 2023, 5:22pm UTC](https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817/5 "2023-04-11T17:22:07Z")
I didn’t use Scanpy for a few months so not sure what I did. I got several errors when using Scanpy. Try to uninstall the package and reinstall it. It worked for one of the errors I got.
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### Author:  [@safa](https://discourse.scverse.org/u/safa)
#### Post date: [July 3, 2023, 12:14pm UTC](https://discourse.scverse.org/t/how-to-fix-modulenotfounderror-no-module-named-skmisc/817/6 "2023-07-03T12:14:03Z")
Hello , I have the same issue . How did u solve it please ?