# Inferring whether a particular disease is closer to other?

**URL:** https://discourse.scverse.org/t/inferring-whether-a-particular-disease-is-closer-to-other/3937
**Category:** General
**Created:** [February 13, 2026, 7:40am UTC](https://discourse.scverse.org/t/inferring-whether-a-particular-disease-is-closer-to-other/3937 "2026-02-13T07:40:19Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![Indianhedgehog](https://avatars.discourse-cdn.com/v4/letter/i/7feea3/32.png) [@Indianhedgehog](https://discourse.scverse.org/u/Indianhedgehog)
#### Post date: [February 13, 2026, 7:40am UTC](https://discourse.scverse.org/t/inferring-whether-a-particular-disease-is-closer-to-other/3937/1 "2026-02-13T07:40:19Z")

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Hi everyone, I have integrated single cells from different diseases. I want to calculate which disease is closer to my disease of interest in terms of gene expression? I have looked up online regarding this, but didn’t much.  
Thanks in advance

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### Author: ![Zethson](https://yyz1.discourse-cdn.com/flex035/user_avatar/discourse.scverse.org/zethson/32/152_2.png) [@Zethson](https://discourse.scverse.org/u/Zethson)
#### Post date: [February 19, 2026, 3:01pm UTC](https://discourse.scverse.org/t/inferring-whether-a-particular-disease-is-closer-to-other/3937/2 "2026-02-19T15:01:57Z")

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Pertpy’s distances might help you:

1. [Distance metrics — pertpy](https://pertpy.readthedocs.io/en/stable/tutorials/notebooks/distances.html)
2. [Distance Tests — pertpy](https://pertpy.readthedocs.io/en/stable/tutorials/notebooks/distance_tests.html)