# Interpretation of fold-changes in differential expression analysis

**URL:** <https://discourse.scverse.org/t/interpretation-of-fold-changes-in-differential-expression-analysis/1437>\
**Category:** scvi-tools\
**Created:** [May 16, 2023, 11:15am UTC](https://discourse.scverse.org/t/interpretation-of-fold-changes-in-differential-expression-analysis/1437 "2023-05-16T11:15:19Z")\
**Posts on this page:** 1\
**Showing post:** 3

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**Author:** ![dkioroglou](https://avatars.discourse-cdn.com/v4/letter/d/dfb087/32.png) [@dkioroglou](https://discourse.scverse.org/u/dkioroglou)\
**Post date:** [May 17, 2023, 9:29am UTC](https://discourse.scverse.org/t/interpretation-of-fold-changes-in-differential-expression-analysis/1437/3 "2023-05-17T09:29:33Z")

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Thank you Valentine for your reply. Your explanation makes sense.

Regarding my second point, similar observations has also been reported by another user ([link to post](https://discourse.scverse.org/t/de-analysis-with-model-scvi-which-lfc-indicates-gene-up-down-regulation/729)), so it would be great if another member of the scVI team could shed some light on this.

Dimitrios

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