About weight and training problems

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1

Hi，
Thank you for your excellent tutorial.

I read the article and code. It seems you split the raw data into source data and target data. I have a question why train VAE separately with respect to different data? Could I this using the source_datasets is trained the model, then using target_datasets trained is like fine-tuning?

And I also see there are two encoders. The front part seems similar, 1003128, 128128. Is these two parts weight shared?

2

Could you specify which tutorial you’re referring to?

3

here is the link
(Multi-Modal Surgery Pipeline with TOTALVI — scArches documentation)

4

For scArches usage, I recommend you make an issue on their github page (GitHub - theislab/scarches: architecture surgery and transfer learning for single-cell)