Prediction of the protein expression based on snRNA-seq

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Hi everybody,

I am wondering if anyone has tried to impute the protein expression values based on single nuclei / cell RNA-seq data. Something like transferring the knowledge from CITE-seq or other experiments where the protein data has not been measured, but the information could be transferred from available other datasets to predict the protein expression value.

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Hi Anatoly,

This is a very interesting use case of single-cell modelling which I am interested in as well! I As far as my knowledge goes there is no module in the scvi-tools library that is specifically designed for this task. However, during my research I came across the scMM model (GitHub - kodaim1115/scMM) which performs cross-modality generation. The model was also explicitly tested on CITE-seq data so this might be in the direction you were thinking?

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