I am currently evaluating Muon to provide the backend for multi-omics, patient level (=not single cell) datasets.
What I have not found yet is if there is already a recommended way/example how to include genomic variants.
My idea was to include them as a separate data layer.
anndata I would have each variant as a variable.
As the data is binary and really sparse, I would have the data matrix to be a sparse matrix with bool datatype.
Would this sound reasonable?